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Caenorhabditis elegans germ line: A model for stem cell biology
Author(s) -
Albert Hubbard E. Jane
Publication year - 2007
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21335
Subject(s) - biology , caenorhabditis elegans , stem cell , developmental biology , context (archaeology) , microbiology and biotechnology , germ cell , germline , population , niche , genetics , ecology , paleontology , demography , sociology , gene
Like many stem cell systems, the Caenorhabditis elegans germ line contains a self‐renewing germ cell population that is maintained by a niche. Although the exact cellular mechanism for self‐renewal is not yet known, three recent studies shed considerable light on the cell cycle behavior of germ cells, including a support for significant and plastic renewal potential. This review brings together the results of the three recent cell‐based studies, places them in the context of previous work, and discusses future perspectives for the field. Developmental Dynamics 236:3343–3357, 2007. © 2007 Wiley‐Liss, Inc.