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Temporal and spatial regulation of bone morphogenetic protein signaling in late lung development
Author(s) -
AlejandreAlcázar Miguel A.,
Shalamanov Petar D.,
Amarie Oana V.,
SevillaPérez Julia,
Seeger Werner,
Eickelberg Oliver,
Morty Rory E.
Publication year - 2007
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21293
Subject(s) - biology , bone morphogenetic protein , lung , microbiology and biotechnology , bone morphogenetic protein 2 , bone formation , signal transduction , medicine , anatomy , endocrinology , genetics , gene , in vitro
Abstract Bone morphogenetic proteins (BMPs) play important roles in early lung development. No study to date has addressed a role for BMP signaling in late lung development. We describe changes in the expression and localization of BMP receptors (Bmpr1a, Bmpr1b, and Bmpr2) and Smad (Smad1, Smad4, Smad5, and Smad8) intracellular signaling proteins during the saccular and alveolarization stages of late lung development. BMP signaling, assessed by Smad1/5 phosphorylation, nuclear translocation, and induction of id1 , id2 , and id3 gene expression, was evident throughout late lung development. Our data indicate that BMP signaling is active during late lung development, and points to roles for the BMP system in septal and vascular development, and in the homeostasis of the epithelial layer of large conducting airways in the mature lung. Developmental Dynamics 236:2825–2835, 2007. © 2007 Wiley‐Liss, Inc.