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Dystroglycan protein distribution coincides with basement membranes and muscle differentiation during mouse embryogenesis
Author(s) -
Anderson Claire,
Winder Steven J.,
Borycki AnneGaëlle
Publication year - 2007
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21259
Subject(s) - dystroglycan , myotome , biology , agrin , basement membrane , microbiology and biotechnology , extracellular matrix , embryogenesis , neural tube , notochord , neural crest , laminin , anatomy , embryo , somite , genetics , acetylcholine receptor , receptor
Using immunohistochemistry, we have examined β‐Dystroglycan protein distribution in the mouse embryo at embryonic stages E9.5 to E11.5. Our data show that Dystroglycan expression correlates with basement membranes in many tissues, such as the notochord, neural tube, promesonephros, and myotome. In the myotome, we describe the timing of Dystroglycan protein re‐distribution at the surface of myogenic precursor cells as basement membrane assembles into a continuous sheet. We also report on non‐basement‐membrane‐associated Dystroglycan expression in the floor plate and the myocardium. This distribution often corresponds to sites of expression previously reported in adults, suggesting that Dystroglycan is continuously produced during development. Developmental Dynamics 236:2627–2635, 2007. © 2007 Wiley‐Liss, Inc.