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Novel gcm ‐dependent lineages in the postembryonic nervous system of Drosophila melanogaster
Author(s) -
Soustelle Laurent,
Giangrande Angela
Publication year - 2007
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21232
Subject(s) - biology , gliogenesis , gcm transcription factors , drosophila melanogaster , embryonic stem cell , neuroscience , fate mapping , ventral nerve cord , lineage (genetic) , central nervous system , anatomy , nervous system , cell fate determination , spinal cord , medulla , embryo , microbiology and biotechnology , neural stem cell , gene , stem cell , transcription factor , genetics , ecology , climate change , general circulation model
glial cells missing genes ( gcm and gcm2 ) act as the glial fate determinants in the Drosophila embryo. However, their requirement in the adult central nervous system (CNS) is at present not known, except for their role in lamina glia. This is particularly important with respect to two recent sets of data. Adult glial subpopulations differentiate through embryonic glia proliferation. Also, gcm ‐ gcm2 are required for the differentiation of specific adult neurons. We here show that gcm is expressed in precursors and postmitotic, migrating, cells of the medulla neuropile glia (mng) lineage. It is also expressed in a thoracic glial lineage and in neurons of the ventral nerve cord (VNC). Finally, while gcm is required for gliogenesis in medulla and VNC, it does not seem to be required for the generation of VNC neurons. Developmental Dynamics 236:2101–2108, 2007. © 2007 Wiley‐Liss, Inc.