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Rapid accumulation of nucleostemin in nucleolus during newt regeneration
Author(s) -
Maki Nobuyasu,
Takechi Katsuaki,
Sano Shozo,
Tarui Hiroshi,
Sasai Yoshiki,
Agata Kiyokazu
Publication year - 2007
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21142
Subject(s) - biology , nucleolus , microbiology and biotechnology , regeneration (biology) , stem cell , planarian , nucleus
Abstract Nucleolar accumulation of nucleostemin in pigmented epithelial cells at the early stage of lens regeneration. In newt regeneration, differentiated cells can revert to stem cell‐like cells in which the proliferative ability and multipotentiality are restored after dedifferentiation. Nucleostemin has been identified in mammals as a nucleolar protein specific to stem cells and cancer cells (Tsai and McKay, 2002). In cover figure, it is shown that nucleostemin (magenta) is rapidly emerged and accumulated in the nucleoli of dedifferentiating pigmented epithelial cells in both dorsal (upper) and ventral iris (lower). From left to right, 0, 2, 4, 6, and 8 days after lentectomy. See Maki et al., Developmental Dynamics 236:941–950