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Diversified expression patterns of autotaxin , a gene for phospholipid‐generating enzyme during mouse and chicken development
Author(s) -
Ohuchi Hideyo,
Hayashibaral Yasunori,
Matsuda Hironao,
Onoi Motoyoshi,
Mitsumori Masayuki,
Tanaka Masayuki,
Aoki Junken,
Arai Hiroyuki,
Noji Sumihare
Publication year - 2007
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21119
Subject(s) - autotaxin , biology , hindbrain , neural tube , floor plate , microbiology and biotechnology , phosphodiesterase , primordium , gene , receptor , embryo , genetics , biochemistry , lysophosphatidic acid , enzyme
Autotaxin (ATX), or nucleotide pyrophosphatase‐phosphodiesterase 2, is a secreted lysophospholipase D that generates bioactive phospholipids that act on G protein–coupled receptors. Here we show the expression patterns of the ATX gene in mouse and chicken embryos. ATX has a dynamic spatial and temporal expression pattern in both species and the expression domains during neural development are quite distinct from each other. Murine ATX ( mATX ) is expressed immediately rostral to the midbrain‐hindbrain boundary, whereas chicken ATX ( cATX ) is expressed in the diencephalon and later in the parencephalon‐synencephalon boundary. In the neural tube, cATX is expressed in the alar plate in contrast to mATX in the floor plate. ATX is also expressed in the hindbrain and various organ primordia such as face anlagen and skin appendages of the mouse and chicken. These results suggest conserved and non‐conserved roles for ATX during neural development and organogenesis in these species. Developmental Dynamics 236:1134–1143, 2007. © 2007 Wiley‐Liss, Inc.

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