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The expression pattern of nuclear receptors during cerebellar development
Author(s) -
Qin Jun,
Suh Jae Mi,
Kim BumJun,
Yu ChengTai,
Tanaka Toshiya,
Kodama Tatsuhiko,
Tsai MingJer,
Tsai Sophia Y.
Publication year - 2007
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21060
Subject(s) - cerebellum , biology , nuclear receptor , receptor , neuroscience , microbiology and biotechnology , transcription factor , genetics , gene
The cerebellum is essential for fine control of movement and posture, and it has been a useful model for studying many aspects of neural development because of its relatively simple anatomy and developmental program. However, the roles of nuclear receptors (NRs) underlying formation of the cerebellum and maintenance of cerebellar functions are still poorly characterized. As a contribution to the Nuclear Receptor Signaling Atlas (NURSA), we employed immunohistochemistry to investigate the expression pattern of 18 NRs in the cerebellum. Ten receptors were demonstrated to be expressed in the postnatal day 21 (P21) cerebellum. Among them, five receptors (COUP‐TFI, COUP‐TFII, RORα, ERβ, and ERRγ) were expressed at all stages (embryonic stage, P0, P7, and P21) examined. Interestingly, COUP‐TFI and COUP‐TFII show differential anterior‐posterior expression patterns during cerebellar development. Taken together, our results suggest that members of the nuclear receptor superfamily might play importantly physiological roles in the cerebellum. Developmental Dynamics 236:810–820, 2007. © 2007 Wiley‐Liss, Inc.