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Comparative analysis of Gata3 and Gata2 expression during chicken inner ear development
Author(s) -
Lilleväli Kersti,
Haugas Maarja,
Pituello Fabienne,
Salminen Marjo
Publication year - 2007
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21011
Subject(s) - inner ear , biology , cochlea , gata3 , gata2 , vestibular system , otic vesicle , microbiology and biotechnology , anatomy , genetics , gene expression , transcription factor , neuroscience , gene , in situ hybridization
The inner ear is a complex sensory organ with hearing and balance functions. Gata3 and Gata2 are expressed in the inner ear, and to gain more insight into their roles in otic development, we made a detailed expression analysis in chicken embryos. At early stages, their expression was highly overlapping. At later stages, Gata2 expression became prominent in vestibular and cochlear nonsensory epithelia. In contrast to Gata2 , Gata3 was mainly expressed in the developing sensory epithelia, reflecting the importance of this factor in the sensory–neural development of the inner ear. While the later expression patterns of both Gata3 and Gata2 were highly conserved between chicken and mouse, important differences were observed especially with Gata3 during early otic development, providing indications of divergent molecular control during placode invagination in mice and chickens. We also found indications that the regulatory hierarchy observed in mouse, where Gata3 is upstream of Gata2 and Fgf10, could be conserved in chicken. Developmental Dynamics 236:306–313, 2007. © 2006 Wiley‐Liss, Inc.