Premium
Expression of claudins in murine tooth development
Author(s) -
Ohazama Atsushi,
Sharpe Paul T.
Publication year - 2007
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.21001
Subject(s) - claudin , biology , primordium , microbiology and biotechnology , in situ hybridization , transmembrane protein , tight junction , genetics , gene , gene expression , receptor
Claudins belong to a family of transmembrane proteins that were identified as components of tight junction strands. We carried out comparative in situ hybridization analysis of 11 claudin genes ( claudin1 – claudin11 ) during murine odontogenesis from the formation of the epithelial thickening to the cytodifferentiation stage. We identify dynamic spatiotemporal expression of 9 of the 11 claudins . At the early bell stage, two claudins ( claudin1 and 4 ) are specifically expressed in stratum intemedium, whereas only one claudin is expressed in each of the preameloblasts ( claudin2 ) and preodontoblasts ( claudin10 ). At the bud stage, when the first epithelial differentiation pathways are being established, localized expression of six claudins ( claudin1 , 3 , 4 , 6 , 7 , and 10 ) identify spatial specific interactions, suggesting a hitherto unobserved complexity of epithelial organization, within the early tooth primordium. Developmental Dynamics 236:290–294, 2007. © 2006 Wiley‐Liss, Inc.