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Differential inhibition of Wnt‐3a by Sfrp‐1, Sfrp‐2, and Sfrp‐3
Author(s) -
Galli Lisa M.,
Barnes Tiffany,
Cheng Tina,
Acosta Lisa,
Anglade Adolph,
Willert Karl,
Nusse Roel,
Burrus Laura W.
Publication year - 2006
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.20856
Subject(s) - biology , wnt signaling pathway , embryo , microbiology and biotechnology , anatomy , gene , genetics
Hamburger Hamilton stage 13 chick embryo was electroporated with constructs encoding Sfrp‐2 (marked by expression of nuclear GFP) and Wnt‐3a (marked by expression of membrane bound GFP) and then incubated until stage 21. A transverse section was then immunostained for Pax‐7 (blue) and antiphosphohistone H3 (red). The upper left panel shows the original image, while the other three panels show digitally manipulated versions of the original image. See Galli et al., Developmental Dynamics 235:681–690. © 2006 Wiley‐Liss, Inc.