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Expression of chondrogenic potential of mouse trunk neural crest cells by FGF2 treatment
Author(s) -
Ido Atsushi,
Ito Kazuo
Publication year - 2006
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.20635
Subject(s) - neural crest , biology , neural fold , chondrogenesis , cranial neural crest , trunk , anatomy , neural plate , fibroblast growth factor , neuroepithelial cell , cartilage , microbiology and biotechnology , embryo , neural stem cell , stem cell , genetics , botany , receptor
There is a significant difference between the developmental patterns of cranial and trunk neural crest cells in the amniote. Thus, whereas cranial neural crest cells generate bone and cartilage, trunk neural crest cells do not contribute to skeletal derivatives. We examined whether mouse trunk neural crest cells can undergo chondrogenesis to analyze how the difference between the developmental patterns of cranial and trunk neural crest cells arises. Our present data demonstrate that mouse trunk neural crest cells have chondrogenic potential and that fibroblast growth factor (FGF) 2 is an inducing factor for their chondrogenesis in vitro. FGF2 altered the expression patterns of Hox9 genes and Id2 , a cranial neural crest cell marker. These results suggest that environmental cues may play essential roles in generating the difference between developmental patterns of cranial and trunk neural crest cells. Developmental Dynamics 235:361–367, 2006. © 2005 Wiley‐Liss, Inc.