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Transgenes as screening tools to probe and manipulate the zebrafish genome
Author(s) -
Amsterdam Adam,
Becker Thomas S.
Publication year - 2005
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.20541
Subject(s) - zebrafish , biology , insertional mutagenesis , enhancer , transgenesis , mutagenesis , transgene , genome , computational biology , genomics , genetics , model organism , functional genomics , genome editing , gene , mutation , gene expression , reproductive biology , embryogenesis
The zebrafish, originally an object of study as an inexpensive and prolific vertebrate embryological model with a plethora of genetic tricks, has over the past decade moved to large‐scale chemical mutagenesis and recently came of age as a high throughput transgenic model with a sequenced genome nearing completion. Insertional mutagenesis, gene trapping and enhancer detection are all contributing to the increasing speed with which research in this biomedical model is progressing. We review here some of the recent developments in the emerging field of zebrafish developmental genomics and transgenesis. Developmental Dynamics 234:255–268, 2005. © 2005 Wiley‐Liss, Inc.