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Comparative analysis of Six3 and Six6 distribution in the developing and adult mouse brain
Author(s) -
Conte Ivan,
Morcillo Julian,
Bovolenta Paola
Publication year - 2005
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.20463
Subject(s) - forebrain , biology , olfactory bulb , neuroscience , thalamus , midbrain , hippocampus , homeobox , cerebellum , prefrontal cortex , transcription factor , anatomy , central nervous system , gene , genetics , cognition
Six3 and Six6 genes are two closely related members of the Six / sine oculis family of homeobox containing transcription factors. Their expression and function at early stages of embryonic development has been widely addressed in a variety of species. However, their mRNA distribution during late embryonic, postnatal, and adult brain barely has been analyzed. Here, we show that despite their initial overlap in the anterior neural plate, the expression of Six3 and Six6 progressively segregates to different regions during mammalian brain development, maintaining only few areas of partial overlap in the thalamic and hypothalamic regions. Six3 , but not Six6 , is additionally expressed in the olfactory bulb, cerebral cortex, hippocampus, midbrain, and cerebellum. These distinct patterns support the idea that Six3 and Six6 are differentially required during forebrain development. Developmental Dynamics 234:718–725, 2005. © 2005 Wiley‐Liss, Inc.