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Fly Six‐type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development
Author(s) -
Kenyon Kristy L.,
Li Dan Jun,
Clouser Christopher,
Tran Susan,
Pigi Francesca
Publication year - 2005
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.20442
Subject(s) - eye development , biology , homeobox , genetics , function (biology) , neuroscience , transcription factor , gene , microbiology and biotechnology
Two members from the Six class of homeobox transcription factors, Sine oculis (SO) and Optix, function during development of the fly visual system. Differences in gain‐of‐function phenotypes and gene expression suggest that these related factors play distinct roles in the formation of the fly eye. However, the molecular nature of their functional differences remains unclear. In this study, we report the identification of two novel factors that participate in specific partnerships with Sine oculis and Optix during photoreceptor neurons formation and in eye progenitor cells. This work shows that different cofactors likely mediate unique functions of Sine oculis and Optix during the development of the fly eye and that the repeated requirement for SO function at multiple stages of eye development reflects the activity of different SO–cofactor complexes. Developmental Dynamics 234:497–504, 2005. © 2005 Wiley‐Liss, Inc.