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Foxc1 integrates Fgf and Bmp signalling independently of twist or noggin during calvarial bone development
Author(s) -
Rice Ritva,
Rice David P.C.,
Thesleff Irma
Publication year - 2005
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.20430
Subject(s) - noggin , fibroblast growth factor , biology , bone morphogenetic protein , microbiology and biotechnology , bone morphogenetic protein 2 , bone morphogenetic protein 7 , ectopic expression , transcription factor , bone morphogenetic protein 5 , anatomy , medicine , receptor , genetics , gene , in vitro
Calvarial bone and suture development is under complex regulation where bone morphogenetic protein (Bmp) and fibroblast growth factor (Fgf) signalling interact with Msx2/Twist and Noggin and regulate frontal bone primordia proliferation and suture fusion, respectively. We have shown previously that the winged helix transcription factor Foxc1, which is necessary for calvarial bone development, is required for the Bmp regulation of Msx2 . We now show that FGF2 regulates the expression of Foxc1 , indicating that Foxc1 integrates Bmp and Fgf signalling pathways. We also show that Foxc1 is not needed for the acquisition of osteogenic potential or for the differentiation of osteoblasts. The expression of Fgf receptors and Twist were normal in Foxc1 ‐deficient calvarial mesenchyme, and ectopic FGF2 was able to induce the expression Osteopontin . Furthermore, we demonstrate that Foxc1 does not participate in the regulation of Noggin expression. Our findings indicate that Foxc1 integrates the Bmp and Fgf signalling pathways independently of Twist or Noggin. This signalling network is essential for the correct patterning and growth of calvarial bones. Developmental Dynamics 233:847–852, 2005. © 2005 Wiley‐Liss, Inc.