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Delayed and disturbed morphogenesis of the umbilical blood vessels in insulin‐like growth factor‐II deficient conceptuses ( Igf2m+/p− )
Author(s) -
Ahmad Amatul Mateen,
Burns Jason,
Gardner Richard,
Graham Chris
Publication year - 2005
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.20320
Subject(s) - conceptus , biology , umbilical cord , allantois , placenta , fetus , endocrinology , medicine , insulin like growth factor , umbilical artery , umbilical vein , andrology , embryo , anatomy , growth factor , pregnancy , microbiology and biotechnology , receptor , genetics , in vitro
Insulin‐like growth factor‐II (IGF‐II) deficiency occurs when a conceptus inherits an inactive gene from the father ( Igf2m+/p− ): fetal wet weight is reduced to 60% of wild‐type, with the decline starting at E11. The umbilical cord vessels of mutant and wild‐type were compared. At E8.0–E8.5, the timing of somite formation and chorioallantoic fusion was not altered. At E14.5–E16.5, the left umbilical artery degenerated approximately 1 day later in Igf2m+/p− conceptuses when compared with the wild‐type. In the common umbilical artery at E15.5, muscle volume was reduced by one third in IGF‐II deficiency. Treating the umbilical arteries as ideal tubes, the values of radius 4 /length suggest that blood flow through the placenta may be reduced by more than half in the Igf2m+/p− conceptuses. Developmental Dynamics 233:88–94, 2005. © 2005 Wiley‐Liss, Inc.