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Novel dominant‐negative mutation within the six domain of the conserved eye specification gene sine oculis inhibits eye development in Drosophila
Author(s) -
Roederer Kristin,
Cozy Loralyn,
Anderson Jason,
Kumar Justin P.
Publication year - 2005
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.20316
Subject(s) - eye development , biology , genetics , compound eye , mutation , gene , drosophila (subgenus) , eye proteins , phenotype , physics , optics
Abstract The development of the compound eye of Drosophila is controlled, in part, by the concerted actions of several nuclear proteins that form an intricate regulatory system. One member of this network is sine oculis ( so ), the founding member of the Six gene family. Mutations within so affect the entire visual system, including the compound eye. The vertebrate homologs Six3 and Six6 also appear to play crucial roles in retinal formation. Mutations in Six3 inhibit retinal formation in chickens and fish, whereas those in Six6 are the underlying cause of bilateral anophthalmia in humans. Together, these phenotypes suggest a conserved role for the Six genes in eye development. In this report, we describe the effects of a dominant‐negative mutation of sine oculis on the development of the compound eye of Drosophila . The mutation resides within the Six domain and may have implications for eye development and disease. Developmental Dynamics 232:753–766, 2005. © 2005 Wiley‐Liss, Inc.