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Functions and mechanisms of receptor tyrosine kinase Torso signaling: Lessons from Drosophila embryonic terminal development
Author(s) -
Li Willis X.
Publication year - 2005
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.20295
Subject(s) - receptor tyrosine kinase , biology , torso , microbiology and biotechnology , platelet derived growth factor receptor , signal transduction , ror1 , receptor protein tyrosine kinases , growth factor receptor , tropomyosin receptor kinase c , tyrosine kinase , receptor , growth factor , genetics , anatomy
The Torso receptor tyrosine kinase (RTK) is required for cell fate specification in the terminal regions (head and tail) of the early Drosophila embryo. Torso contains a split tyrosine kinase domain and belongs to the type III subgroup of the RTK superfamily that also includes the platelet‐derived growth factor receptors, stem cell or steel factor receptor c‐Kit proto‐oncoprotein, colony‐stimulating factor‐1 receptor, and vascular endothelial growth factor receptor. The Torso pathway has been a model system for studying RTK signal transduction. Genetic and biochemical studies of Torso signaling have provided valuable insights into the biological functions and mechanisms of RTK signaling during early Drosophila embryogenesis. Developmental Dynamics 232:656–672, 2005. © 2005 Wiley‐Liss, Inc.