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Characterization of Opr deficiency in mouse brain: Subtle defects in dorsomedial telencephalon and medioventral forebrain
Author(s) -
Furushima Kenryo,
Murata Takuya,
Kiyonari Hiroshi,
Aizawa Shinichi
Publication year - 2005
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.20253
Subject(s) - forebrain , biology , neuroectoderm , cerebrum , midbrain , gastrulation , basal forebrain , anatomy , neuroscience , microbiology and biotechnology , embryonic stem cell , genetics , gene , central nervous system , mesoderm
Opr / Zic5 is a zinc‐finger gene belonging to, and unique in, the opa / Zic family. Its expression is found in the anterior epiblast and anterior neuroectoderm during gastrulation and early neurulation. Later, we found the expression characteristic in the dorsomedial parts of forebrain and midbrain. However, no defects were apparent in embryonic day 10.5 Opr null mutants, and subtle defects were later found in medial pallium and ventral structures of forebrain, suggesting the compensation of Opr deficiency by its cognate(s). Developmental Dynamics 232:1056–1061, 2005. © 2005 Wiley‐Liss, Inc.