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Ephrin signaling in vivo: Look both ways
Author(s) -
Davy Alice,
Soriano Philippe
Publication year - 2005
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.20200
Subject(s) - ephrin , erythropoietin producing hepatocellular (eph) receptor , biology , axon guidance , angiogenesis , microbiology and biotechnology , eph receptor a2 , signal transduction , neuroscience , neural crest , receptor , embryo , genetics , axon , receptor tyrosine kinase
Abstract Eph receptors and ephrins have captured the interest of the developmental biology community in recent years for their pleiotropic functions during embryogenesis. Loss‐of‐function studies using various animal models have demonstrated the involvement of Ephs and ephrins in many aspects of embryogenesis including segmentation, neural crest cells migration, angiogenesis, and axon guidance. An essential property of this signaling pathway is the ability of both Ephs and ephrins to behave as receptors or ligands and their consequent cell autonomous and nonautonomous mode of action. While many reports did not discriminate between Eph autonomous signaling (forward) and ephrin autonomous signaling (reverse), recent genetic and in vivo studies have shown that both forward and reverse signaling play important roles during embryogenesis. Developmental Dynamics 232:1–10, 2005. © 2004 Wiley‐Liss, Inc.