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Stat3 signaling is present and active during development of the central nervous system and eye of vertebrates
Author(s) -
Yan Ye,
Bian Wei,
Xie Zhiqin,
Cao Xinmin,
Le Roux Isabelle,
Guillemot Francois,
Jing Naihe
Publication year - 2004
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.20126
Subject(s) - biology , stat3 , neural tube , electroporation , in ovo , stat protein , microbiology and biotechnology , central nervous system , embryo , embryonic stem cell , embryogenesis , signal transduction , neuroscience , genetics , gene
Stat3, a member of the signal transducer and activator of transcription (STAT) family, plays a central role in mediating cell growth, differentiation, and survival signals. In this report, we show that Stat3 immunoreactivity was localized to specific regions in the developing mouse brain, neural tube, and eye from embryonic day 10.5 to postnatal day 0. The active form of Stat3 protein, which is phosphorylated on tyrosine 705 (pYStat3), was also found in the developing neural tube with more restricted distribution. An in ovo chick embryo electroporation assay showed that the endogenous chick Stat3 could drive consensus sis‐inducible element‐directed reporter gene expression. These results demonstrate that the active Stat3 protein is present and might play a role during the development of the central nervous system and eye. Developmental Dynamics 231:248–257, 2004. © 2004 Wiley‐Liss, Inc.