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Creation of a transgenic mouse for hair‐cell gene targeting by using a modified bacterial artificial chromosome containing Prestin
Author(s) -
Tian Yong,
Li Mingyuan,
Fritzsch Bernd,
Zuo Jian
Publication year - 2004
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.20106
Subject(s) - biology , inner ear , cre recombinase , hair cell , bacterial artificial chromosome , genetically modified mouse , transgene , microbiology and biotechnology , recombinase , vestibular system , epididymis , gene , anatomy , genetics , sperm , neuroscience , genome , recombination
We made a transgenic mouse that expresses Cre recombinase activity in inner ear hair cells by using a modified bacterial artificial chromosome containing Prestin . Cre recombinase activity was restricted to inner and outer hair cells, a subset of vestibular hair cells, spiral and vestibular ganglia in the inner ear, and a subset of cells in the testis, epididymis, and ear bone. This mouse will be useful for hair‐cell–specific gene targeting. Developmental Dynamics 231:199–203, 2004. © 2004 Wiley‐Liss, Inc.