Creation of a transgenic mouse for hair‐cell gene targeting by using a modified bacterial artificial chromosome containing  Prestin | Zendy

Tian Yong | Zendy; Li Mingyuan | Zendy; Fritzsch Bernd | Zendy; Zuo Jian | Zendy

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Creation of a transgenic mouse for hair‐cell gene targeting by using a modified bacterial artificial chromosome containing Prestin

Author(s) -

Tian Yong,

Li Mingyuan,

Fritzsch Bernd,

Zuo Jian

Publication year - 2004

Publication title -

developmental dynamics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.634

H-Index - 141

eISSN - 1097-0177

pISSN - 1058-8388

DOI - 10.1002/dvdy.20106

Subject(s) - biology , inner ear , cre recombinase , hair cell , bacterial artificial chromosome , genetically modified mouse , transgene , microbiology and biotechnology , recombinase , vestibular system , epididymis , gene , anatomy , genetics , sperm , neuroscience , genome , recombination

We made a transgenic mouse that expresses Cre recombinase activity in inner ear hair cells by using a modified bacterial artificial chromosome containing Prestin . Cre recombinase activity was restricted to inner and outer hair cells, a subset of vestibular hair cells, spiral and vestibular ganglia in the inner ear, and a subset of cells in the testis, epididymis, and ear bone. This mouse will be useful for hair‐cell–specific gene targeting. Developmental Dynamics 231:199–203, 2004. © 2004 Wiley‐Liss, Inc.

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