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Fibulin‐2 expression marks transformed mesenchymal cells in developing cardiac valves, aortic arch vessels, and coronary vessels
Author(s) -
Tsuda Takeshi,
Wang Hui,
Timpl Rupert,
Chu MonLi
Publication year - 2001
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.1172
Subject(s) - fibulin , mesenchymal stem cell , extracellular matrix , biology , microbiology and biotechnology , vasculogenesis , neural crest , anatomy , heart development , angiogenesis , endocardium , embryonic stem cell , medicine , embryo , cancer research , stem cell , progenitor cell , biochemistry , gene
Previous studies showed that extracellular matrix protein, fibulin‐2, is expressed during epithelial–mesenchymal transformation in the endocardial cushion matrix during embryonic heart development. Our current study revealed that, in addition to the cardiac valvuloseptal formation, fibulin‐2 is synthesized by the smooth muscle precursor cells of developing aortic arch vessels and the coronary endothelial cells that are originated from neural crest cells and epicardial cells, respectively. In the cardiac valves and the aortic arch vessels, fibulin‐2 expression shows robust up‐regulation when the transformed mesenchymal cells migrate into the existing extracellular matrix. In the epicardium, epicardial cells produce fibulin‐2 upon their migration over the myocardial surface and its expression persists throughout coronary vasculogenesis and angiogenesis. Fibulin‐2 is produced by the endothelial cells of coronary arteries and veins but not by the capillary endothelial cells in the myocardium. Thus, fibulin‐2 not only uniquely marks the transformed mesenchymal cells during mouse embryonic cardiovascular development, but also indicates vascular endothelial cells of coronary arteries and veins in postnatal life. © 2001 Wiley‐Liss, Inc.