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Becoming glial in the neural retina
Author(s) -
Vetter Monica L.,
Moore Kathryn B.
Publication year - 2001
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.1145
Subject(s) - biology , gliogenesis , microbiology and biotechnology , retina , muller glia , notch signaling pathway , neurogenesis , progenitor cell , neuroscience , cell fate determination , neural stem cell , cyclin dependent kinase , neural development , cell cycle , signal transduction , stem cell , cell , genetics , transcription factor , gene
During development of the vertebrate neural retina, multipotent stem cells give rise to retinal neurons as well as to Müller cells, the principal glial population in the retina. Recent studies have shed light upon the extracellular and intracellular signaling pathways that regulate Müller glial cell genesis. Emerging evidence demonstrates that activation of the Notch signaling pathway can play a role in regulating Müller cell development as well as gliogenesis in other parts of the central nervous system. Cyclin dependent kinase (CDK) inhibitors of the Cip/Kip subfamily are cell cycle regulators that can regulate progenitor proliferation during retinal development, but also regulate the proliferation of Müller glia when they become activated in response to stress or injury. Surprisingly this class of proteins can also promote the development of Müller glia. In this review we discuss the role of both Notch and the CDK inhibitors in regulating Müller cell development. © 2001 Wiley‐Liss, Inc.