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Zebrafish E‐cadherin: Expression during early embryogenesis and regulation during brain development
Author(s) -
Babb Sherry G.,
Barnett Jessica,
Doedens Andrew L.,
Cobb Nicole,
Liu Qin,
Sorkin Barbara C.,
Yelick Pamela C.,
Raymond Pamela A.,
Marrs James A.
Publication year - 2001
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.1132
Subject(s) - biology , gastrulation , zebrafish , microbiology and biotechnology , hindbrain , cadherin , embryogenesis , cdh1 , mesoderm , endoderm , fgf8 , embryo , blastomere , epiboly , engrailed , anatomy , genetics , homeobox , gene expression , embryonic stem cell , gene , cell , receptor , fibroblast growth factor
Zebrafish E‐cadherin ( cdh1 ) cell adhesion molecule cDNAs were cloned. We investigated spatial and temporal expression of cdh1 during early embryogenesis. Expression was observed in blastomeres, the anterior mesoderm during gastrulation, and developing epithelial structures. In the developing nervous system, cdh1 was detected at the pharyngula stage (24 hpf) in the midbrain‐hindbrain boundary (MHB). Developmental regulation of MHB formation involves wnt1 and pax2.1 . wnt1 expression preceded cdh1 expression during MHB formation, and cdh1 expression in the MHB was dependent on normal development of this structure. © 2001 Wiley‐Liss, Inc.