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Sonic hedgehog patterning in chick neural plate is antagonized by a Wnt3‐like signal
Author(s) -
Robertson Christie P.,
Braun Michelle M.,
Roelink Henk
Publication year - 2004
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.10501
Subject(s) - sonic hedgehog , neural tube , biology , wnt signaling pathway , hedgehog , neural cell , neural plate , microbiology and biotechnology , floor plate , hedgehog signaling pathway , neural fold , cell fate determination , neural development , dorsum , neuroscience , cell , anatomy , signal transduction , embryo , genetics , transcription factor , gene
Sonic hedgehog (Shh) patterns the dorsal‐ventral axis of the neural tube by promoting the differentiation of ventral neural cell types while suppressing dorsal neural fates. Other signals impinge upon the Shh response, biasing the differentiation of a cell. Three dorsally expressed transforming Wnts, of which the most broadly expressed is Wnt3 , may be among the signals that influence the Shh response. We demonstrate that activation of Wnt signaling results in an inhibition of the Shh response in neural tissue. Additionally, we show that the expression pattern of chick Wnt3 is consistent with a role in neural patterning. These results indicate that differentiating neural tube cells, besides integrating signals from Hedgehogs and BMPs, may also incorporate a Wnt response to make cell fate decisions. Developmental Dynamics 229:510–519, 2004. © 2004 Wiley‐Liss, Inc.