Premium
Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development
Author(s) -
Wright Tracy J.,
Hatch Ekaterina P.,
Karabagli Hakan,
Karabagli Pinar,
Schoenwolf Gary C.,
Mansour Suzanne L.
Publication year - 2003
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.10362
Subject(s) - otic vesicle , biology , fibroblast growth factor , inner ear , hindbrain , ectoderm , microbiology and biotechnology , fibroblast growth factor receptor 4 , fibroblast growth factor receptor , morphogenesis , fgf10 , fibroblast growth factor receptor 2 , endocrinology , fibroblast growth factor receptor 3 , medicine , embryogenesis , anatomy , genetics , receptor , embryo , gene expression , gene , in situ hybridization
The inner ear, which mediates hearing and equilibrium, develops from an ectodermal placode located adjacent to the developing hindbrain. Induction of the placode and its subsequent morphogenesis and differentiation into the inner ear epithelium and its sensory neurons, involves signalling interactions within and between otic and non‐otic tissues. Several members of the fibroblast growth factor (FGF) family play important roles at various stages of otic development; however, there are additional family members that have not been evaluated. In this study, we surveyed the expression patterns of 18 mouse Fgf and 3 Fgf receptor ( Fgfr ) genes during early otic development. Two members of the Fgf family, Fgf4 and Fgf16 , and all three tested members of the Fgfr family, Fgfr2c , Fgfr3c , and Fgfr4 , were expressed in tissues relevant to inner ear development. Fgf4 transcripts were expressed in the preplacodal and placodal ectoderm, suggesting potential roles in placode induction and/or maintenance. Fgf16 was expressed in the posterior otic cup and vesicle, suggesting roles in otic cell fate decisions and/or axis formation. Development Dynamics 228:267–272, 2003. © 2003 Wiley‐Liss, Inc.