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Transitions in the model of epithelial patterning
Author(s) -
Přibyl Michal,
Muratov Cyrill B.,
Shvartsman Stanislav Y.
Publication year - 2003
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.10218
Subject(s) - biology , drosophila melanogaster , microbiology and biotechnology , oocyte , epidermal growth factor receptor , drosophila (subgenus) , phenotype , model system , pattern formation , epithelium , gene regulatory network , computational biology , biological system , evolutionary biology , gene , gene expression , genetics , receptor , embryo
We analyze pattern formation in the model of cell communication in Drosophila egg development. The model describes the regulatory network formed by the epidermal growth factor receptor (EGFR) and its ligands. The network is activated by the oocyte‐derived input that is modulated by feedback loops within the follicular epithelium. We analyze these dynamics within the framework of a recently proposed mathematical model of EGFR signaling (Shvartsman et al. [2002] Development 129:2577–2589). The emphasis is on the large‐amplitude solutions of the model that can be correlated with the experimentally observed patterns of protein and gene expression. Our analysis of transitions between the major classes of patterns in the model can be used to interpret the experimentally observed phenotypic transitions in eggshell morphology in Drosophila melanogaster . The existence of complex patterns in the model can be used to account for complex eggshell morphologies in related fly species. © 2002 Wiley‐Liss, Inc.