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A zebrafish unc‐45 –related gene expressed during muscle development
Author(s) -
Etheridge Letitiah,
Diiorio Philip,
Sagerström Charles G.
Publication year - 2002
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.10123
Subject(s) - biology , zebrafish , myosin , gastrulation , mesoderm , caenorhabditis elegans , microbiology and biotechnology , tetratricopeptide , skeletal muscle , gene , anatomy , myocyte , blastoderm , somitogenesis , genetics , embryogenesis , somite , embryonic stem cell
We report the isolation and expression pattern of zebrafish unc45r , a gene related to Caenorhabditis elegans unc‐45 . UNC‐45 is a muscle‐specific protein thought to interact with myosin and promote the assembly of muscle thick filaments during C. elegans development. Zebrafish Unc45r shares sequence features with C. elegans UNC‐45, including three tetratricopeptide repeats and a CRO1/She4p homology domain. unc45r is expressed in mesoderm adjacent to the dorsal midline during late gastrula stages and is coexpressed with muscle specific genes in somitic mesoderm during development of trunk skeletal muscle. unc45r is also expressed in cranial skeletal muscle as well as in cardiac and smooth muscle. The isolation of a muscle‐specific unc‐45 related gene from zebrafish suggests a common mechanism for muscle filament assembly between vertebrates and invertebrates. © 2002 Wiley‐Liss, Inc.