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Vibrational spectroscopic study of salbutamol hemisulphate
Author(s) -
Ali H. R. H.,
Edwards H. G. M.,
Kendrick J.,
Scowen I. J.
Publication year - 2009
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.8
Subject(s) - salbutamol , raman spectroscopy , infrared , chemistry , infrared spectroscopy , molecule , fourier transform infrared spectroscopy , molecular vibration , computational chemistry , analytical chemistry (journal) , organic chemistry , physics , medicine , optics , asthma
Salbutamol hemisulphate is a relatively selective β 2 ‐adrenergic agonist and is used as a bronchodilator. In this work, we present a detailed vibrational spectroscopic investigation of salbutamol hemisulphate using mid‐infrared and near‐infrared Fourier‐transform (NIR‐FT) Raman spectroscopies. These data are supported by quantum chemical calculations, which allow us to characterise the vibrational spectra of this compound reasonably. As such, this study could be viable for examining the way in which this drug interacts with its target molecules. Copyright © 2009 John Wiley & Sons, Ltd.