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Voltammetric determination of sulfamethoxazole at a multiwalled carbon nanotube modified glassy carbon sensor and its application studies
Author(s) -
Issac Sindhu,
Girish Kumar K.
Publication year - 2009
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.69
Subject(s) - nafion , detection limit , supporting electrolyte , electrochemistry , carbon nanotube , chemistry , electrolyte , horizontal scan rate , nuclear chemistry , sulfamethoxazole , voltammetry , glassy carbon , electrode , cyclic voltammetry , chromatography , materials science , nanotechnology , biochemistry , antibiotics
Sulfamethoxazole (SMX) is an anti‐bacterial sulfonamide. It prevents the formation of dihydrofolic acid, a compound that bacteria need in order to survive. The present work details the voltammetric analysis of SMX at a multiwalled carbon nanotube (MWCNT)‐Nafion modified glassy carbon electrode (GCE). Sulfamethoxazole gives a well defined oxidation peak at 0.74 V in 0.1 M phosphate buffer solution (PBS) of pH 8.0. The experimental parameters such as the amount of MWCNT‐Nafion suspension, the pH of the supporting electrolyte and scan rate were optimized and a direct electrochemical method for the determination of SMX was developed. Under optimum conditions the oxidation peak current is linear to the concentration of SMX in the range 1 × 10 −2 − 5 × 10 −5 M with a detection limit of 1 × 10 −5 M. The MWCNT/GCE showed good stability, selectivity and was successfully used to quantify SMX in pharmaceutical formulations and urine sample. Copyright © 2009 John Wiley & Sons, Ltd.