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Recent instrumental progress in mass spectrometry: advancing resolution, accuracy, and speed of drug detection
Author(s) -
Thevis Mario,
Volmer Dietrich A.
Publication year - 2012
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.344
Subject(s) - orbitrap , mass spectrometry , fourier transform ion cyclotron resonance , ion trap , electrospray ionization , chemistry , bioanalysis , clinical toxicology , time of flight mass spectrometry , analytical chemistry (journal) , drug detection , ionization , nanotechnology , chromatography , ion , materials science , organic chemistry , biology , toxicology
Fast and unequivocal drug detection is of considerable importance in numerous fields of analytical chemistry, and today mass spectrometry‐based approaches are often the method of choice due to their sensitive and specific nature. Mass spectrometry is in constant flux with innovations and thus supports the development of new, complementary assays for rapid determination of drugs and toxins as well as their metabolic products in clinical, forensic, and doping control laboratories. Examples of such innovations that have greatly aided the worldwide bioanalytical efforts are the modern improvements in ion trap, for example, Fourier transform‐ion cyclotron resonance (FT‐ICR) mass spectrometer ‐ Orbitrap, and time‐of‐flight (TOF) mass analyzers when coupled with sensitive ionization techniques such as electrospray ionization. In this perspective, the utility of state‐of‐the‐art mass spectrometers and recent instrumental developments such as new and/or improved hybrid analyzers are discussed and selected applications presented. Copyright © 2012 John Wiley & Sons, Ltd.