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Dried blood spots for anti‐doping: Why just going volumetric may not be sufficient
Author(s) -
Luginbühl Marc,
Gaugler Stefan
Publication year - 2021
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.2977
Subject(s) - perspective (graphical) , dried blood , blood sampling , doping , population , sampling (signal processing) , biomedical engineering , medicine , statistics , computer science , materials science , chromatography , chemistry , mathematics , artificial intelligence , telecommunications , optoelectronics , environmental health , detector
The perspective discusses quantitative DBS analysis for anti‐doping testing in an athletic population and why only using volumetric sampling for this subgroup might not be enough. It presents examples to highlight where HCT variations occur, followed by a whole blood to plasma ratio and an HCT extraction bias discussion. Finally, options to correct for the HCT bias are presented.