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Paper spray mass spectrometry – A potential complementary technique for the detection of polar compounds in sports drug testing
Author(s) -
Görgens Christian,
Walker Katherine,
Boeser Cornelia,
Wijeratne Neloni,
Martins Claudia,
Guddat Sven,
Thevis Mario
Publication year - 2020
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.2909
Subject(s) - chromatography , mass spectrometry , analyte , chemistry , tandem mass spectrometry , sample preparation , analytical chemistry (journal)
In this proof‐of‐concept study, paper spray mass spectrometry was investigated as a high‐throughput and fully automated technique for the initial testing of particularly polar compounds that are prohibited in sports. The technique allows the ionization of analytes from complex sample matrices such as blood and urine when spotted onto a paper strip. By minimizing sample preparation and omitting chromatographic separation, paper spray mass spectrometry benefits from considerable cost‐ and time‐savings compared with conventional high performance liquid chromatography/tandem mass spectrometry, especially in cases where conventional reversed‐phase liquid chromatography offers limited applicability. All but one of the investigated model compounds fulfilled the World Anti‐Doping Agency's (WADA's) requirements regarding the applicable minimum required performance limits for initial testing procedures. In addition, the combination of paper spray mass spectrometry and ion mobility separation results in enhanced selectivity and sensitivity and is a particularly valuable analytical configuration.