Premium
Glycine‐modified growth hormone secretagogues identified in seized doping material
Author(s) -
Gajda Paulina Marta,
Holm Niels Bjerre,
Hoej Lars Jakobsen,
Rasmussen Brian Schou,
Dalsgaard Petur Weihe,
Reitzel Lotte Ask,
Linnet Kristian
Publication year - 2019
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.2489
Subject(s) - glycine , growth hormone , chemistry , chromatography , hormone , amino acid , mass spectrometry , biochemistry
A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP‐2 (Pralmorelin), GHRP‐6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1–29), which can be used as performance‐enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N ‐terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.