Premium
Profiling of new psychoactive substances by using stable isotope ratio mass spectrometry: Study of the synthetic cannabinoid 5F‐PB‐22
Author(s) -
MünsterMüller S.,
Scheid N.,
Holdermann T.,
Schneiders S.,
Pütz M.
Publication year - 2018
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.2407
Subject(s) - chemistry , mass spectrometry , isotope ratio mass spectrometry , analyser , synthetic cannabinoids , cannabinoid , isotope , chromatography , stable isotope ratio , analytical chemistry (journal) , biochemistry , physics , receptor , quantum mechanics
Abstract In this paper, the results of a pilot study on the profiling of the synthetic cannabinoid receptor agonist 5F‐PB‐22 (5F‐QUPIC, pentylfluoro‐1 H ‐indole‐3‐carboxylic acid‐8‐quinolinyl ester) via isotope ratio mass spectrometry are presented. It focuses on δ 13 C, δ 15 N and δ 2 H isotope ratios, which are determined using elemental analyser (EA) and high temperature elemental analyser (TC/EA) coupled to an isotope ratio mass spectrometer (IRMS). By means of a sample of pure material of 5F‐PB‐22, it is shown that the extraction of 5F‐PB‐22 from herbal material, a rapid clean‐up procedure, or preparative column chromatography had no influence on the isotope ratios. Furthermore, 5F‐PB‐22 was extracted from 14 different herbal blend samples (“Spice products” from police seizures) and analysed via IRMS, yielding 3 clusters containing 7, 5, and 2 samples, distinguishable through their isotopic composition, respectively. It is assumed that herbal blends in each cluster have been manufactured from individual batches of 5F‐PB‐22.