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Voltammetric determination of promethazine hydrochloride at a multi‐wall carbon nanotube modified glassy carbon electrode
Author(s) -
Xi Xia,
Ming Liang,
Liu Jie
Publication year - 2011
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.205
Subject(s) - carbon nanotube , detection limit , phenothiazine , electrochemistry , glassy carbon , materials science , promethazine , electrode , anode , analytical chemistry (journal) , chromatography , nanotechnology , chemistry , cyclic voltammetry , medicine , anesthesia , pharmacology
A simple and sensitive method is described for voltammetric determination of promethazine hydrochloride (PMZ), a widely used phenothiazine drug, based on its electrochemical oxidation at a multi‐wall carbon nanotube (MWCNT) modified glassy carbon electrode (GCE). Compared with bare GCE, the MWCNT‐modified GCE exhibited excellent enhancement effect on the electrochemical oxidation of PMZ. PMZ yielded two anodic peaks at about 0.61 V and 0.78 V, and the peak at 0.61 V was applied to the determination. Under optimized conditions, the anodic peak current was linear to the concentration of PMZ in the range from 5.0 × 10 −8 to 4.0 × 10 −4 M with the detection limit of 1.0 × 10 −8 M. The relative standard deviation (RSD) was 2.28% for 8.0 × 10 −6 M PMZ ( n = 10). To further validate its possible application, the proposed method was successfully used for the quantification of PMZ in pharmaceutical formulations and biological fluids with satisfactory results. Copyright © 2010 John Wiley & Sons, Ltd.