Premium
High throughput‐screening of animal urine samples: It is fast but is it also reliable?
Author(s) -
Kaufmann Anton
Publication year - 2016
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.2022
Subject(s) - urine , chromatography , detection limit , veterinary drugs , high resolution , veterinary drug , drug , chemistry , computer science , medicine , pharmacology , veterinary medicine , remote sensing , geology
Advanced analytical technologies like ultra‐high‐performance liquid chromatography coupled to high resolution mass spectrometry can be used for veterinary drug screening of animal urine. The technique is sufficiently robust and reliable to detect veterinary drugs in urine samples of animals where the maximum residue limit of these compounds in organs like muscle, kidney, or liver has been exceeded. The limitations and possibilities of the technique are discussed. The most critical point is the variability of the drug concentration ratio between the tissue and urine. Ways to manage the false positive and false negatives are discussed. The capability to confirm findings and the possibility of semi‐targeted analysis are also addressed. Copyright © 2016 John Wiley & Sons, Ltd.