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Identification and analytical characterization of four synthetic cathinone derivatives iso‐4‐BMC, β ‐TH‐naphyrone, mexedrone, and 4‐MDMC
Author(s) -
Qian Zhenhua,
Jia Wei,
Li Tao,
Liu Cuimei,
Hua Zhendong
Publication year - 2017
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.1983
Subject(s) - chemistry , mass spectrometry , cathinone , gas chromatography–mass spectrometry , synthetic cannabinoids , chromatography , street drugs , gas chromatography , stereochemistry , pharmacology , psychology , medicine , biochemistry , cannabinoid , amphetamine , receptor , drug , neuroscience , dopamine
New psychoactive substances (NPS) have gained much popularity on the global market over the last number of years. The synthetic cathinone family is one of the most prominent groups and this paper reports on the analytical properties of four synthetic cathinone derivatives: ( 1 ) 1‐(4‐bromophenyl)‐1‐(methylamino)propan‐2‐one (iso‐4‐BMC or iso‐brephedrone), ( 2 ) 2‐(pyrrolidin‐1‐yl)‐1‐(5,6,7,8‐tetrahydronaphthalen‐2‐yl)pentan‐1‐one ( β ‐TH‐naphyrone), ( 3 ) 3‐methoxy‐2‐(methylamino)‐1‐(4‐methylphenyl)propan‐1‐one (mexedrone), and ( 4 ) 2‐(dimethylamino)‐1‐(4‐methylphenyl)propan‐1‐one (4‐MDMC). These identifications were based on liquid chromatography‐quadrupole time‐of‐flight‐mass spectrometry (LC‐QTOF‐MS), gas chromatography‐mass spectrometry (GC‐MS) and nuclear magnetic resonance (NMR) spectroscopy. To our knowledge, no chemical or pharmacological data about compounds 1–3 have appeared until now, making this the first report on these compounds. The Raman and GC‐MS data of 4 have been reported, but this study added the LC‐MS and NMR data for additional characterization. Copyright © 2016 John Wiley & Sons, Ltd.