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Detection of phenazepam in illicitly manufactured Erimin 5 tablets
Author(s) -
Lim Wendy J.L.,
Yap Angeline T.W.,
Mangudi Merula,
Koh H.B.,
Tang Angeline S.Y.,
Chan K.B.
Publication year - 2017
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.1981
Subject(s) - chromatography , thin layer , chemistry , thin layer chromatography , medicine , layer (electronics) , organic chemistry
A validated ultra‐high‐performance liquid chromatographic (UHPLC) method was used to determine the phenazepam dosage in clandestinely produced Erimin 5 tablets. Tablets from five different seizures submitted to the laboratory in 2013 were found to have a dosage of about 2.4 milligrams. The measurement uncertainty of the assay was estimated to be 3.2 % (relative) at a coverage factor of k=2. As an adjunct study the dyes in the tablets from several seizures were determined by thin‐layer chromatography (TLC) for future comparative studies.