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Two‐dimensional correlation infrared spectroscopy applied to the identification of ephedrine and pseudoephedrine in illegally adulterated slimming herbal products
Author(s) -
Miao Li,
Liu Yan,
Li Hao,
Qi Yunpeng,
Lu Feng
Publication year - 2017
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.1963
Subject(s) - pseudoephedrine , ephedrine , chemistry , fourier transform infrared spectroscopy , high resolution , two dimensional nuclear magnetic resonance spectroscopy , infrared spectroscopy , chromatography , analytical chemistry (journal) , stereochemistry , medicine , organic chemistry , physics , pharmacology , remote sensing , quantum mechanics , geology
Two‐dimensional correlation spectroscopy (2DCOS) was employed for the identification of ephedrine (Ep) and pseudoephedrine (Ps) present in illegally adulterated slimming herbal products (SHPs). Second derivative (SD) spectral pretreatment was used prior to 2DCOS analysis to highlight specific features not readily observable by Fourier transform infrared spectroscopy (FTIR), SD‐FTIR, or original 2DCOS, leading to enhanced resolution and a reduced lower limit of detection (<1% in this study). After examining the power spectra of suspicious SHPs, bands containing characteristic peaks for Ep (701, 747, 1042, 1363, 1375, 1451, 1478 cm ‐1 etc) and/or Ps (703, 767, 1037, 1375, 1428, 1455, 1590 cm ‐ 1, etc.) were selected to construct synchronous and asynchronous maps for further analysis, while the latter was applied to discriminate positive SHPs adulterated simultaneously with Ep and Ps. The proposed method is simple and economical and has the potential to identify other chemicals in illegally adulterated herbal products. Copyright © 2016 John Wiley & Sons, Ltd.