Spatial distribution of theobromine – a low MW drug – in tissues via matrix‐free NALDI‐MS imaging | Zendy

Tata Alessandra | Zendy; Montemurro Chiara | Zendy; Porcari Andreia M. | Zendy; Silva Kamila C. | Zendy; Lopes de Faria José B. | Zendy; Eberlin Marcos N. | Zendy

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Spatial distribution of theobromine – a low MW drug – in tissues via matrix‐free NALDI‐MS imaging

Author(s) -

Tata Alessandra,

Montemurro Chiara,

Porcari Andreia M.,

Silva Kamila C.,

Lopes de Faria José B.,

Eberlin Marcos N.

Publication year - 2014

Publication title -

drug testing and analysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.065

H-Index - 54

eISSN - 1942-7611

pISSN - 1942-7603

DOI - 10.1002/dta.1691

Subject(s) - theobromine , chemistry , desorption , mass spectrometry imaging , matrix assisted laser desorption/ionization , mass spectrometry , matrix (chemical analysis) , laser , analytical chemistry (journal) , chromatography , adsorption , caffeine , organic chemistry , optics , physics , medicine , endocrinology

The ability of nano‐assisted laser desorption‐ionization mass spectrometry imaging (NALDI‐IMS) to provide selective chemical monitoring with appropriate spatial distribution of a low molecular drug in a biological tissue was investigated. NALDI‐IMS is a matrix‐free laser desorption ionization (LDI) protocol based on imprinting of tissue constituents on a nanostructured surface. Using the accumulation of theobromine in rat kidney as a model, NALDI‐IMS was found to provide well‐resolved images of the special distribution of this low molecular weight (MW) drug in tissue. Copyright © 2014 John Wiley & Sons, Ltd.

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