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Spatial distribution of theobromine – a low MW drug – in tissues via matrix‐free NALDI‐MS imaging
Author(s) -
Tata Alessandra,
Montemurro Chiara,
Porcari Andreia M.,
Silva Kamila C.,
Lopes de Faria José B.,
Eberlin Marcos N.
Publication year - 2014
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.1691
Subject(s) - theobromine , chemistry , desorption , mass spectrometry imaging , matrix assisted laser desorption/ionization , mass spectrometry , matrix (chemical analysis) , laser , analytical chemistry (journal) , chromatography , adsorption , caffeine , organic chemistry , optics , physics , medicine , endocrinology
The ability of nano‐assisted laser desorption‐ionization mass spectrometry imaging (NALDI‐IMS) to provide selective chemical monitoring with appropriate spatial distribution of a low molecular drug in a biological tissue was investigated. NALDI‐IMS is a matrix‐free laser desorption ionization (LDI) protocol based on imprinting of tissue constituents on a nanostructured surface. Using the accumulation of theobromine in rat kidney as a model, NALDI‐IMS was found to provide well‐resolved images of the special distribution of this low molecular weight (MW) drug in tissue. Copyright © 2014 John Wiley & Sons, Ltd.