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Dried blood spots: Concepts, present status, and future perspectives in bioanalysis
Author(s) -
Sharma Abhisheak,
Jaiswal Swati,
Shukla Mahendra,
Lal Jawahar
Publication year - 2014
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.1646
Subject(s) - bioanalysis , dried blood , dried blood spot , context (archaeology) , blood sampling , therapeutic drug monitoring , medical physics , sampling (signal processing) , medicine , computer science , pharmacokinetics , pharmacology , chemistry , chromatography , biology , paleontology , filter (signal processing) , computer vision
Over the past several years, dried blood spot (DBS) sampling technique has emerged as a pertinent method in both qualitative and quantitative bioanalysis context. In the DBS method, the blood sample is directly soaked on to a paper (with or without treatment). After drying it can be analyzed by modern analytical, immunological, or genomic detection systems. Several advantages of the DBS technique such as low blood volume requirement, transportation and storage without special treatment, better analytes stability, enhanced clinical cooperation in clinical trials, and reduced unforeseeable exposure of analysts to biohazards, make it the most appropriate blood sampling technique. This review illustrates the information available on the DBS method which may serve as a single window for investigators in the field of bioanalysis. Also, it explores the proficiency and appliance of the DBS method in pharmacokinetic (PK), therapeutic drug monitoring (TDM), toxicokinetic (TK), metabolomic, and disease diagnosis. Copyright © 2014 John Wiley & Sons, Ltd.