Premium
Study of collision‐induced dissociation of electrospray‐generated protonated cathinones
Author(s) -
Fornal Emilia
Publication year - 2013
Publication title -
drug testing and analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 54
eISSN - 1942-7611
pISSN - 1942-7603
DOI - 10.1002/dta.1573
Subject(s) - dissociation (chemistry) , chemistry , protonation , electrospray , collision induced dissociation , collision , mass spectrometry , tandem mass spectrometry , chromatography , computer science , organic chemistry , computer security , ion
The collision‐induced dissociation (CID) pathways of electrospray‐generated protonated cathinones were examined to help elucidate the structures of new cathinone‐based designer drugs by high performance liquid chromatography coupled with high‐resolution tandem mass spectrometry. Quadrupole time‐of‐flight product spectra were obtained for 39 substituted cathinones and were analyzed to derive general CID fragmentation pathways. Nine classes of cathinones were characterized based on structural criteria, including the molecular double bond equivalent and the characteristics of the amine group. For each class of cathinones, we determined the characteristic CID fragmentation pathways, and identified the primary and some specific higher‐order product ions. Copyright © 2013 John Wiley & Sons, Ltd.