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Impact of maternal immune activation on dendritic spine development
Author(s) -
Pekala Martyna,
Doliwa Marta,
Kalita Katarzyna
Publication year - 2021
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.22804
Subject(s) - biology , dendritic spine , neuroscience , immune system , immunology , cognitive science , psychology , hippocampal formation
Dendritic spines are small dendritic protrusions that harbor most excitatory synapses in the brain. The proper generation and maturation of dendritic spines are crucial for the regulation of synaptic transmission and formation of neuronal circuits. Abnormalities in dendritic spine density and morphology are common pathologies in autism and schizophrenia. According to epidemiological studies, one risk factor for these neurodevelopmental disorders is maternal infection during pregnancy. This review discusses spine alterations in animal models of maternal immune activation in the context of neurodevelopmental disorders. We describe potential mechanisms that might be responsible for prenatal infection‐induced changes in the dendritic spine phenotype and behavior in offspring.