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The tubulin code specializes neuronal cilia for extracellular vesicle release
Author(s) -
Akella Jyothi S.,
Barr Maureen M.
Publication year - 2021
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.22787
Subject(s) - cilium , intraflagellar transport , microtubule , biology , microbiology and biotechnology , extracellular , tubulin , organelle , extracellular vesicle , vesicle , neuroscience , microvesicles , flagellum , biochemistry , microrna , gene , membrane
Cilia are microtubule‐based organelles that display diversity in morphology, ultrastructure, protein composition, and function. The ciliary microtubules of C. elegans sensory neurons exemplify this diversity and provide a paradigm to understand mechanisms driving ciliary specialization. Only a subset of ciliated neurons in C. elegans are specialized to make and release bioactive extracellular vesicles (EVs) into the environment. The cilia of extracellular vesicle releasing neurons have distinct axonemal features and specialized intraflagellar transport that are important for releasing EVs. In this review, we discuss the role of the tubulin code in the specialization of microtubules in cilia of EV releasing neurons.