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Spinal Cord Regeneration in Amphibians: A Historical Perspective
Author(s) -
Freitas Polina D.,
Yandulskaya Anastasia S.,
Monaghan James R.
Publication year - 2019
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.22669
Subject(s) - biology , regeneration (biology) , neuroscience , spinal cord , central nervous system , amphibian , perspective (graphical) , evolutionary biology , ecology , microbiology and biotechnology , artificial intelligence , computer science
In some vertebrates, a grave injury to the central nervous system (CNS) results in functional restoration, rather than in permanent incapacitation. Understanding how these animals mount a regenerative response by activating resident CNS stem cell populations is of critical importance in regenerative biology. Amphibians are of a particular interest in the field because the regenerative ability is present throughout life in urodele species, but in anuran species it is lost during development. Studying amphibians, who transition from a regenerative to a nonregenerative state, could give insight into the loss of ability to recover from CNS damage in mammals. Here, we highlight the current knowledge of spinal cord regeneration across vertebrates and identify commonalities and differences in spinal cord regeneration between amphibians.