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N euronal I ntrinsic R egenerative C apacity: T he I mpact of M icrotubule O rganization and A xonal T ransport
Author(s) -
Murillo Blanca,
Mendes Sousa Mónica
Publication year - 2018
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.22602
Subject(s) - growth cone , biology , axon , microtubule , cytoskeleton , microbiology and biotechnology , neuroscience , axoplasmic transport , dorsal root ganglion , nervous system , central nervous system , regeneration (biology) , axon guidance , spinal cord , cell , biochemistry
In the adult vertebrate central nervous system, axons generally fail to regenerate. In contrast, peripheral nervous system axons are able to form a growth cone and regenerate upon lesion. Among the multiple intrinsic mechanisms leading to the formation of a new growth cone and to successful axon regrowth, cytoskeleton organization and dynamics is central. Here we discuss how multiple pathways that define the regenerative capacity converge into the regulation of the axonal microtubule cytoskeleton and transport. We further explore the use of dorsal root ganglion neurons as a model to study the neuronal regenerative ability. Finally, we address some of the unanswered questions in the field, including the mechanisms by which axonal transport might be modulated by injury, and the relationship between microtubule organization, dynamics, and axonal transport. © 2018 Wiley Periodicals, Inc. Develop Neurobiol 00: 000–000, 2018