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Microglial modulation of neuronal activity in the healthy brain
Author(s) -
York Elisa M.,
Bernier LouisPhilippe,
MacVicar Brian A.
Publication year - 2018
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.22571
Subject(s) - microglia , neuroscience , biology , central nervous system , neuronal circuits , premovement neuronal activity , brain function , homeostasis , biological neural network , immunology , inflammation , microbiology and biotechnology
Investigations on the role of microglia in the brain have traditionally been focused on their contributions to disease states. However, recent observations have now convincingly shown that microglia in the healthy brain are not passive bystanders, but instead play a critical role in both central nervous system development and homeostasis of synaptic circuits in the adult. Here, we review the various mechanisms by which microglia impact neuronal communication in the healthy adult brain, both by sensing nearby synaptic responses and by actively modulating neuronal function. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 593–603, 2018