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EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure
Author(s) -
Robichaux Michael A.,
Chenaux George,
Ho HsinYi Henry,
Soskis Michael J.,
Greenberg Michael E.,
Henkemeyer Mark,
Cowan Christopher W.
Publication year - 2016
Publication title -
developmental neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.716
H-Index - 129
eISSN - 1932-846X
pISSN - 1932-8451
DOI - 10.1002/dneu.22323
Subject(s) - anterior commissure , forebrain , biology , commissure , corpus callosum , neuroscience , intracellular , axon guidance , receptor , anatomy , white matter , axon , microbiology and biotechnology , central nervous system , genetics , radiology , medicine , magnetic resonance imaging
The two cortical hemispheres of the mammalian forebrain are interconnected by major white matter tracts, including the corpus callosum (CC) and the posterior branch of the anterior commissure (ACp), that bridge the telencephalic midline. We show here that the intracellular signaling domains of the EphB1 and EphB2 receptors are critical for formation of both the ACp and CC. We observe partial and complete agenesis of the corpus callosum, as well as highly penetrant ACp misprojection phenotypes in truncated EphB1/2 mice that lack intracellular signaling domains. Consistent with the roles for these receptors in formation of the CC and ACp, we detect expression of these receptors in multiple brain regions associated with the formation of these forebrain structures. Taken together, our findings suggest that a combination of forward and reverse EphB1/2 receptor‐mediated signaling contribute to ACp and CC axon guidance. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 405–420, 2016